Bone Abstracts

As a bone-derived hormone that regulates phosphate homeostasis and renal 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] production, fibroblast growth factor (FGF)-23 has been postulated to indirectly control calcium and bone metabolism by modulating the levels of phosphate and 1,25(OH)2D3. However, the presence of FGF receptor-1 (FGFR-1) proteins in the intestinal epithelial cells suggests that the intestine may directly respond t...

A decrease or absence of beta-globin production in erythroid cells causes a hereditary anemic disorder known as beta-thalassemia, which is associated with ineffective erythropoiesis, iron overload, growth retardation, osteopenia, and osteoporosis. Our recent investigation revealed that beta-thalassemia led to osteoclast-mediated bone resorption and the impaired intestinal calcium absorption, the latter of which modestly responded to conventional 1,25-dihydroxyvitamin D3</...

Breastfeeding leads to marked trabecular bone loss as a result of high osteoclast- and osteocyte-mediated bone resorption. It has long been postulated that adequate dietary calcium intake prevents maternal bone loss, nevertheless, whether calcium supplement alleviates maternal bone mechanical property need to be investigated. Herein, we hypothesized that calcium supplement from natural sources could alleviate bone loss and improve mechanical property in lactating rats. During ...